Abdominal obesity, specifically visceral fat, may raise colorectal cancer risk. Colorectal cancer is the third most frequent cancer worldwide.
Inflammation: Metabolically active visceral fat in the abdomen produces inflammatory chemicals. Chronic inflammation may contribute to cancer growth and progression.
Insulin Resistance: Obesity often causes insulin resistance. Insulin resistance can raise insulin levels, which may increase cancer cell development.
Adipose tissue (fat) produces hormones and signaling molecules called adipokines. Leptin and adiponectin imbalances may cause cancer. Increased estrogen levels in adipose tissue have been associated to colorectal cancer.
Gut Microbiota: Obesity, specifically abdominal obesity, can change gut microbiota. Colorectal cancer risk increases with gut microbiota changes.
Absence of physical activity: Sedentary lifestyles are linked to abdominal obesity, which increases colorectal cancer risk. Regular exercise protects against cancer.
While abdominal obesity is linked to colorectal cancer, the relationship is complex and may be affected by diet, genetics, and lifestyle. Not all people with abdominal obesity get colorectal cancer, and the risk is complex.
Colorectal cancer risk may be reduced by regular exercise, a balanced diet rich in fruits and vegetables, and weight management. For those at risk, colorectal cancer screening is crucial to detect and treat early malignant tumors.
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